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-synuclein, and that is a main ingredient of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which happens to be an E3 ubiquitin ligase and brings about endoplasmic reticulum (ER) worry, propose that dysfunction of the intracellular proteinase methods, which include ubiquitin-proteasome system or lysosomal program, which gets rid of